The Adaptive Particle Representation (APR) is an alternative image representation to pixel images for realizing the next generation of imaging pipelines using light-sheet fluorescence microscopy. The APR addresses computational, memory, and storage bottlenecks by adapting the image resolution to the local image content. Unlike standard image compression, the adaptive computational and memory...
Light penetration and formation of image inside biological tissues is of physiological relevance in the eye and practical importance in the context of tissue and whole organism microscopy. We present here how the vertebrate retina, having a counter intuitive inverted structure deals with incoming light. We show by direct transmission measurements how the unique chromatin arrangement within...
Continuous advancements in microscopy and sample preparation methods such as clearing or expansion allow for the investigation of ever larger samples at high resolution. This entails increasingly large datasets that may consist of hundreds of images of one sample that are not aligned, suffer from optical disturbances and often cannot even be opened as a whole, which can pose a serious...
