The PAR network polarizes a broad range of cell types by localizing proteins to opposing membrane domains. Despite its abundance, we know almost nothing about how the PAR proteins adapt to this vast diversity of cell sizes and shapes. In many systems, maintenance of polarity has been described as a reaction-diffusion network of the proteins involved.
Here, by first using theoretical...
Conventional light sheet fluorescence microscopy (LSFM) requires two microscope objective lenses orientated at 90° to one another. However, their proximity to one another and the sample makes high content imaging of samples mounted on conventional 96 and 384-well plates difficult. Oblique plane microscopy (OPM)1 uses a single high numerical aperture microscope objective to provide both...
