This Indico installation shall not be used to organise MPI-CBG courses and events from beginning of 2024 on. Please use MPG Indico instead.
20-23 August 2019
Hotel Amfora, Hvar, Croatia
Europe/Berlin timezone

How the size of a cell can determine its fate

Not scheduled
20m
Terrace ballroom (Hotel Amfora, Hvar, Croatia)

Terrace ballroom

Hotel Amfora, Hvar, Croatia

Ul. Biskupa Jurja Dubokovica 5, 21450, Hvar, Croatia

Speaker

Dr Julia Pfanzelter (BIOTEC)

Description

Production of viable oocytes is an essential process during sexual reproduction. The C. elegans gonad is composed of roughly 1000 germ cells, half of which develop into oocytes while the rest undergo apoptosis. These dying cells are thought to act as nurse cells donating material to their growing neighbours. Long-range cytoplasmic flows through the connecting tube of this syncytial tissue promote the growth of oocytes, however it remains unknown what triggers cell death in the C. elegans gonad. One hypothesis is that cell size becomes a determining factor that destines smaller cells for apoptosis and larger ones for becoming oocytes. To test this hypothesis I employed FLUCS, a microscopy-based manipulation technique that allows me to create cytoplasmic flows in the germ line. By directing flows into or out of a cell its size can be changed and with that also its fate. While in control cells apoptosis is only triggered in 15% of the cases, inducing flows out of a germ cell leads to cell death in over 50% of the manipulated cells. This indicates that cell size is a critical parameter in the decision between life and death in C. elegans germ cells.
While it has been reported that cell size can influence cell fate decisions also in other systems, it remains unclear how cell size is sensed, especially in a syncytial structure such as the C. elegans gonad.

Primary author

Dr Julia Pfanzelter (BIOTEC)

Co-authors

Prof. Frank Julicher (MPIPKS Dresden) Dr Sebastian Fürthauer (Flatiron Institute ) Nicolas Chartier (TU Dresden) Arghyadip Mukherjee (MPI-PKS) Prof. Stephan Grill (MPI-CBG)

Presentation Materials

There are no materials yet.
Your browser is out of date!

Update your browser to view this website correctly. Update my browser now

×