Biophysical Conference 2019

Session

Not scheduled

Terrace ballroom (Hotel Amfora, Hvar, Croatia)

Contribution list Timetable

17. A single molecule perspective on the role of biomolecular condensation in FUS mediated DNA damage repair

Mr Roman Renger (MPI-CBG)

Talk

Biomolecular condensation (BC) has recently been found to govern the spatial and temporal organization of the intracellular space with respect to various processes. FUS (Fused in Sarcoma) is an intrinsically disordered protein that forms condensates at sites of DNA damage in vivo and liquid-like droplets that harden over time in vitro. A detailed picture of the assembly process of FUS based...

21. Balance of forces and torques in a mean-field approximation in mitotic spindles

Arian Ivec (Faculty of Science, University of Zagreb)

Talk

The mitotic spindle is a self-organized micro-machine composed of microtubules and associated proteins, which divides genetic material between its two nascent daughter cells. Forces exist in the spindle throughout mitosis and are crucial for spindle functioning in each phase. In metaphase, the mitotic spindle has a recognizable shape with a characteristic arrangement of microtubules....

31. Dynamics of microtubule bundle formation during prometaphase

Dr Juraj Simunić (Ruđer Bošković Institute)

Talk

The spindle during metaphase consists of evenly distributed and well-organized microtubule bundles. It is unknown how this recognizable architecture arises during prometaphase. Here we show that during prometaphase the spindle contains antiparallel PRC1 labelled bundles the number of which increases in time by longitudinal splitting of preexisting bundles and by de novo assembly. By using live...

26. Extreme-Value Statistics of Molecular Motors

Mr Alexandre Guillet (ICTP and LOMA)

Talk

We derive exact expressions for the finite-time statistics of extrema (maximum and minimum) of the spatial displacement and the fluctuating entropy flow of continuous-time random walks describing the dynamics of molecular motors at the single-molecule level. Our results generalize the infimum law for entropy production and reveal a symmetry of the distribution of maxima and minima of...

38. In vivo perturbation of active forces in the actomyosin cortex of C. elegans embryo

Dora Polic

Talk

Morphogenesis is one of the fundamental processes during development. Critically, it depends on the generation of forces by the actomyosin cortex: a dynamic contractile apparatus that emerges from the cooperative interaction between actin networks and non-muscle myosin II (Alberts, B. et al., 2008, Philips, R. et al., 2012, Salbreux, G. et al., 2012). The past decades have brought a detailed...

8. Understanding how temperature affects the fertility of Caenorhabditis elegans by studying the liquid-like properties of P granules

Mark Leaver, Stephan Grill

Talk

Because of ongoing climate change, we urgently need to know what effect temperature has on the fertility of cold blooded organisms. Fertility has a complex response to temperature, for example it effecting development and the reproductive output of C. elegans. At extremes of high and low temperatures, the development of the gonad (the organ which produces sperm and eggs) fails and *C....