This Indico installation shall not be used to organise MPI-CBG courses and events from beginning of 2024 on. Please use MPG Indico instead.
11-13 June 2018
Palace Brunow, Poland
Europe/Berlin timezone

How the human neocortex folds - a novel role of the extracellular matrix

13 Jun 2018, 09:50
Postdoc talk Session VI


Katherine Long (MPI-CBG)


Neocortical expansion is thought to underlie the cognitive traits that are unique to humans. This evolutionary expansion is accompanied by cortical folding, which starts to form from around gestational weeks (GW) 20. However, what causes it remains largely unknown. Extracellular matrix (ECM) has been previously implicated in neocortical expansion and here we investigate the potential role of ECM in the formation of neocortical folds. We focus on three specific ECM components localized in the human fetal cortical plate: hyaluronan and proteoglycan link protein 1 (HAPLN1), lumican and collagen I (collectively, HLC). Addition of HLC to cultures of human fetal neocortex (11-22 GW) caused local changes in tissue stiffness, induced cortical plate folding, increased hyaluronic acid (HA) in the cortical plate and required the HA-receptor CD168 and its downstream ERK signaling. Importantly, loss of HA reduced HLC-induced and 22 GW physiological nascent folds and this process was altered in samples with neurodevelopmental disorders, indicating it may be a useful system to study such disorders.

Primary author

Presentation Materials

There are no materials yet.
Your browser is out of date!

Update your browser to view this website correctly. Update my browser now