Ágnes Tóth-Petróczy did her PhD, at the Weizmann Institute of Science, Rehovot, Israel. She studied the paths of evolving protein sequences under the supervision of Prof. Tawfik. In 2014, she moved to Harvard University in Boston to start a postdoctorat in the group of Prof Marks. As postdoctoral research fellow, she studied the structured states of disordered proteins from genomic sequences....
Changes in mammalian genomes reflect the evolution of distinct phenotypic traits. For instance, these phenotypic traits comprise adaptations to different habitats, diets, and morphological changes. Such changes can lead to the loss of protein-coding genes that do not serve advantageous or essential functions for the corresponding species. Our group previously developed a method for accurately...
Tight junctions form a border between the apical and basolateral plasma-membrane domains and are linked to the machinery that controls apicobasal polarization. This achieved by adhesion/polymerization of the claudin protein family and the interactions with the scaffold proteins on the cytoplasmic side. The main proteins family in the scaffold is the MAGUK family, especially the zona occludens...
Epithelial cell polarization is a fundamental organizing principle during early embryonic development, and later differentiation into specific tissues and organs. It is known that epithelial transition involves asymmetry, where cells polarize into apical, lateral, and basal plasma membrane domains. However, how the identity of the polarized membrane is established and communicated to the...
