Timothy Nott did his PhD on molecular structure at the National Institute for Medical Research in London under the supervision of Dr. Smerdon. He graduated in 2009 and moved to Toronto to study the principles of how cells are internally compartmentalised in the group of Professor Pawson. He started as Postdoctoral Research Associate in 2014 (Professor Baldwin) at the university of Oxford...
The processes that contribute to protein expression are subject to stochastic fluctuations and are affected by the environment in which they operate. As a result, concentration of a given protein can vary greatly between organisms, cells, as well as in time. Since many biological processes demand a tight control over protein concentration, cells have evolved various mechanisms to control the...
Neocortical expansion is thought to underlie the cognitive traits that are unique to humans. This evolutionary expansion is accompanied by cortical folding, which starts to form from around gestational weeks (GW) 20. However, what causes it remains largely unknown. Extracellular matrix (ECM) has been previously implicated in neocortical expansion and here we investigate the potential role of...
